Electro-Optical Detection of Single Nanoparticles on a Nanopore-Optofluidic Chip. Issue 1720 (30th December 2014)

• Record Type: Journal Article
• Authors: Liu, Shuo; Zhao, Yue; Stott, Matthew; Parks, Joshua W.; Hawkins, Aaron R.; Schmidt, Holger
• Editors: Fan, X.; Liu, L.; Park, E.; Schmidt, H.
• Is Part Of: MRS proceedings. Issue 1720:(2014)
• Publication Date: 2014-12-30
• Subjects: sensor, -- nanoscale, -- optoelectronic; Electrical engineering -- Congresses; Physics -- Congresses; Materials -- Research -- Congresses; Materials science -- Congresses; 620.11
• DOI: 10.1557/opl.2014.954
• Languages: English
• ISSNs: 0272-9172

Abstract

ABSTRACT: A solid-state nanopore was integrated into an optofluidic sensor chip, liquid-core anti-resonant reflecting optical waveguide (ARROW). The solid-state nanopore worked as a smart gate, which simultaneously provided characteristic electrical signals and controlled the entry of single nanoparticles into the liquid-core channel. The subsequent fluorescence detection further identified the nanoparticles by providing optical signals within a specific wavelength range. In this work, correlated electrical and optical detection of single nanoparticles, H1N1 viruses, and λ-DNA molecules was demonstrated. Different types of particles in a mixture were successfully discriminated. Moreover, the flow velocity in the liquid-core channel was extracted with the help of combined analysis of electrical and optical signals. Enhanced electrical sensitivity using a solid-state nanopore with a thin limiting aperture sculpted by SiO2 deposition was also shown.