Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects: A randomize-controlled trial. (December 2015)

• Record Type: Journal Article
• Authors: Lee, Hsiu-Chuan; Cheng, Wen-Yi; Hsu, Yi-Hao; Su, Hsiu-Yueh; Huang, Brian E. T.-G.; Lin, Yen-Kuang; Chan, Wing P.; Su, Chien-Tien; Huang, Shih-Yi
• Is Part Of: Journal of functional foods. Volume 19:Part B(2016)
• Page Start: 929
• Page End: 940
• Publication Date: 2015-12
• Subjects: MetS metabolic syndrome -- T2DM type 2 diabetes mellitus -- LC-PUFA long-chain polyunsaturated fatty acid -- hsCRP high-sensitivity C-reactive protein -- TMU Taipei Medical University -- TMUH Taipei Medical University Hospital -- WFH Wan Fang Hospital -- BMI body mass index -- WC waist circumference -- TG triacylglycerol -- FBG fasting blood glucose -- SBP systolic blood pressure -- DBP diastolic blood pressure -- AIDS acquired immunodeficiency syndrome -- CR calorie-restriction -- CRMR calorie-restriction meal replacement -- CRF calorie-restriction with fish oil -- CRMRF calorie-restriction meal replacement with fish oil -- OGTT oral glucose tolerance test -- DEXA dual-energy x-ray absorptiometry -- BP blood pressure -- MAP mean arterial pressure -- HOMA-IR homeostasis model assessment of insulin resistance -- QUICKI quantitative insulin sensitivity check index -- EDA eicosadienoic acid -- AA arachidonic acid -- ALA α-linolenic acid -- EPA eicosapentaenoic acid -- DPA docosapentaenoic acid -- DHA docosahexaenoic acid -- Hb hemoglobin -- CRP C-reactive protein -- IL interleukin -- TC total cholesterol -- LDLc low-density lipoprotein-cholesterol -- SD standard deviation -- ANOVA analysis of variance -- PC postprandial glucose; Metabolic syndrome -- n-3 long-chain polyunsaturated fatty acids -- n-6/n-3 ratio; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2015.01.040
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: All groups had significant reduction in waist circumference, blood pressure, and other cardiometabolic parameters. The MetS severity decreased significantly post-intervention and correlated with the serum IL-6 level and n-6/n-3 ratio. Calorie-restricted conditions improved cardiometabolic parameters, including circulating fatty acid profile and IL-6 level. No adverse effects of LC-PUFA and meal replacement treatments were observed. Abstract: Metabolic syndrome (MetS) increases the risk of type 2 DM and cardiovascular disease. We here evaluated the effects of a calorie-restriction diet with 2.13 g/day n-3 long-chain polyunsaturated fatty acid supplementation in MetS patients. The 188 participants were randomly assigned one of four calorie-restriction diets for 12 weeks: calorie-restriction (n = 44), calorie-restriction meal replacement (n = 45), calorie-restriction with fish oil (n = 44), or calorie-restriction meal replacement with fish oil (n = 44); 179 participants completed the trial. After treatment, all groups had significant reduction in waist circumference, blood pressure, and cardiometabolic parameters. Results indicate that long-chain polyunsaturated fatty acid (LC-PUFA) supplementation under calorie-restriction exert beneficial effects on metabolic parameters.