Fish oil and multivitamin supplementation reduces oxidative stress but not inflammation in healthy older adults: A randomised controlled trial. (December 2015)

• Record Type: Journal Article
• Authors: Pipingas, Andrew; Sinclair, Andrew; Croft, Kevin D.; Januszewski, Andrzej S.; Jenkins, Alicia J.; Mori, Trevor A.; Cockerell, Robyn; Grima, Natalie A.; Stough, Con; Scholey, Andrew; Myers, Stephen P.; Sali, Avni; Pase, Matthew P.
• Is Part Of: Journal of functional foods. Volume 19:Part B(2016)
• Page Start: 949
• Page End: 957
• Publication Date: 2015-12
• Subjects: ANZCTR Australia and New Zealand Clinical Trials Registry -- AA arachidonic acid -- CVD cardiovascular disease -- CRP C reactive protein -- DHA docosahexaenoic acid -- EDTA ethylenediaminetetraacetic acid -- EPA eicosapentaenoic acid -- HDL high density lipoprotein -- LC n-3 PUFA long chain omega-3 polyunsaturated fatty acids -- LDL low density lipoprotein -- n-3 omega-3 -- n-6 omega-6 -- RBC red blood cells -- RCT randomised controlled trial -- ROS reactive oxygen species; Fish oil -- PUFA -- Multivitamins -- Inflammation -- Oxidative stress -- F2-isoprostanes; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2014.10.028
• Languages: English
• ISSNs: 1756-4646

Abstract

Abstract: The effects of daily fish oil supplementation, with and without multivitamins, on biochemical markers of health were examined. Healthy adults ( N = 160) were randomised to receive 3 g of salmon oil with a multivitamin, 6 g of salmon oil with a multivitamin, 6 g of salmon oil in isolation or placebo in a double-blind fashion on a daily basis for 16 weeks. Relative to placebo, both 6 g salmon oil groups displayed significantly lower F2 -isoprostane levels at endpoint. Increases in red blood cell polyunsaturated fatty acids correlated with reductions in F2 -isoprostanes. Treatment had no effect on inflammatory cytokines, C-reactive protein, fibrinogen, cholesterol or triacylglycerol.