Immune imbalance of regulatory T/type 2 helper cells in the pathogenesis of allergic rhinitis in children. Issue 1 (1st December 2015)

• Record Type: Journal Article
• Authors: Sun, R; Tang, X-Y; Yang, Y
• Is Part Of: Journal of laryngology & otology. Volume 130:Issue 1(2016)
• Page Start: 89
• Page End: 94
• Publication Date: 2015-12-01
• Subjects: Allergic Rhinitis, -- Regulatory T Cells, -- Th2 Cells, -- FOXP3 Protein, -- Human, -- GATA3 Protein; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1017/S0022215115003096
• Languages: English
• ISSNs: 0022-2151

Abstract

Abstract: Objectives: To determine the role of regulatory T/type 2 helper cell-mediated immune imbalance in the pathogenesis of allergic rhinitis and examine the association between clinical severity and regulatory T/type 2 helper cell-mediated immune imbalance. Methods: Levels of interleukins 4 and 5 and transforming growth factor β1, and expression of FOXP3 and GATA3 (which are functionally related to regulatory T and type 2 helper cells, respectively), were evaluated in 46 allergic rhinitis patients and 42 healthy subjects. Results: Compared to controls, allergic rhinitis patients showed significantly higher interleukin 4 and 5 levels, but lower transforming growth factor β1 levels. Furthermore, FOXP3 messenger RNA expression was lower in allergic rhinitis patients, while GATA3 messenger RNA and protein expression was significantly higher. Regulatory T/type 2 helper cell ratio was inversely correlated with clinical symptom scores. Conclusion: Regulatory T/type 2 helper cell immune imbalance may contribute to allergic rhinitis development. These findings provide a new insight into disease pathogenesis and potential therapeutic approaches.