Rapid Detection of Sildenafil Drugs in Liquid Nutraceuticals Based on Surface‐Enhanced Raman Spectroscopy Technology. Issue 10 (3rd July 2017)

• Record Type: Journal Article
• Authors: Zhao, Hang; Hasi, Wuliji; Bao, Lin; Han, Siqingaowa; Sha, Xuanyu; Sun, Jia; Lou, Xiutao; Lin, Dianyang; Lv, Zhiwei
• Is Part Of: Chinese journal of chemistry. Volume 35:Issue 10(2017)
• Page Start: 1522
• Page End: 1528
• Publication Date: 2017-07-03
• Subjects: sildenafil -- surface‐enhanced Raman spectroscopy -- density functional theory -- limit of detection; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201700168
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract : In this study, surface‐enhanced Raman spectroscopy (SERS) technology was used to rapidly detect illegally added sildenafil drugs. A detailed attribution analysis by density functional theory (DFT) was used to guide specific experiments. The Raman signals were obtained from a silver colloid (Ag col) substrate, and they increased in the presence of the mineral salt, potassium iodide (KI). These methods detected sildenafil in aqueous solutions as low as 1 µg/mL with high signal uniformity (RSD=3.77%). Prior to this study, traditional Raman techniques detected substances in solid samples only. Here, Raman technology detected low contents of sildenaful drugs in liquid nutraceuticals. Therefore, SERS technology has great potential for on‐site and real‐time detection of illegal drugs in water and in liquid nutraceuticals. Abstract : A detailed attribution analysis by density functional theory (DFT) was used to guide the surface‐enhanced Raman spectroscopy experiments. The SERS signals were obtained from a silver colloid (Ag col) substrate and mineral salts. Here, Raman technology detected low contents of sildenaful drugs in liquid nutraceuticals. Therefore, SERS technology has great potential for on‐site and real‐time detection of illegal drugs in water and in liquid nutraceuticals.