Malignant Adenomyoepithelioma of the Breast: A Review. Issue 3 (13th March 2015)

• Record Type: Journal Article
• Authors: Ahmadi, Nasrollah; Negahban, Shahrzad; Aledavood, Azita; Daneshbod, Khosrow; Daneshbod, Yahya
• Is Part Of: Breast journal. Volume 21:Issue 3(2015:May/Jun.)
• Page Start: 291
• Page End: 296
• Publication Date: 2015-03-13
• Subjects: cytology -- fine‐needle aspiration -- histopathology -- immunohistochemistry -- literature review -- malignant adenomyoepithelioma; Breast -- Diseases -- Periodicals; Breast -- Cancer -- Periodicals; 618.19
• DOI: 10.1111/tbj.12390
• Languages: English
• ISSNs: 1075-122X

Abstract

Abstract: Malignant adenomyoepithelioma (MAME) of the breast is a rare lesion characterized by dual population of epithelial and myoepithelial cells which one or both components show malignant features. We report a case of MAME of the breast in a 46‐year‐old woman diagnosed by fine‐needle aspiration with extensive review of the literature. Classification, clinical presentation, cyto‐pathologic, and immunohistochemical features are described. This lesion showed both malignant components of epithelial and myoepithelial cells in cytology and histology. The malignancy was convincingly supported by high mitotic figures, pleomorphism, and invasion in tissue sections. This review of MAMEs showed that cyto‐histologic diagnosis is difficult and should be supported by immunohistochemical study.