Infants with prenatally diagnosed kidney anomalies have an increased risk of urinary tract infections. (4th September 2017)

• Record Type: Journal Article
• Authors: Rasmussen, Maria; Sunde, Lone; Andersen, René F.; Petersen, Olav B.; Olsen, Morten S.
• Other Names: Tabor Ann investigator.; Shalmi Anne‐Cathrine investigator.; Jensen Hanne investigator.; Vase Laura investigator.; Sperling Lene investigator.; Vang Marianne investigator.; Hessellund Annette investigator.; Brendstrup Lene investigator.; Bendsen Eske investigator.; Sommer Steffen investigator.; Kamper Christina investigator.; Zingenberg Helle investigator.; Krebs Lone investigator.; Thisted Dorte investigator.; Skibsted Lillian investigator.; Olesen Annette investigator.; Sørensen Anne investigator.; Størup Birgitte investigator.
• Is Part Of: Acta pædiatrica. Volume 106:Number 11(2017)
• Page Start: 1875
• Page End: 1881
• Publication Date: 2017-09-04
• Subjects: Kidney dysplasia -- Mortality -- Parenchymal kidney anomalies -- Prenatal screening -- Urinary tract infections; Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.14014
• Languages: English
• ISSNs: 0803-5253

Abstract

Abstract: Aim: This study estimated the urinary tract infection (UTI) risk in a nationwide cohort of infants prenatally diagnosed with parenchymal kidney anomalies compared with a comparison cohort. Methods: A Danish population‐based nationwide cohort of foetuses diagnosed with parenchymal kidney anomalies between 2007 and 2012 had previously been identified. These were compared with foetuses without kidney anomalies who were prenatally scanned the same year. Live born infants were followed from birth until the diagnosis of UTI, emigration, death or two years of age. Cumulative incidences of UTIs were computed. Mortality was estimated using the Kaplan–Meier method. Results: We identified 412 foetuses with parenchymal kidney anomalies out of 362 069 who underwent ultrasound scans and 277 were born alive. The overall risk of a UTI before the age of two years was 19%, and it was 14% among infants without prenatally diagnosed co‐occurring urinary tract malformations. The corresponding risk in the 4074 controls was 1%. After two years, mortality was 2.2% in infants with prenatally diagnosed parenchymal kidney anomalies and 0.2% in the controls. Conclusion: Infants prenatally diagnosed with parenchymal kidney anomalies had a substantially increased risk of UTI. Awareness of this increased risk may facilitate earlier diagnosis of UTIs in this population.