Microstructural mechanisms of analgesia in percutaneous cervical cordotomy revealed by diffusion tensor imaging. (November 2017)

• Record Type: Journal Article
• Authors: Gebarski, Stephen S.; Chiravuri, Srinivas; Foerster, Bradley R.; Patil, Parag G.
• Is Part Of: Journal of clinical neuroscience. Volume 45(2017:Nov.)
• Page Start: 311
• Page End: 314
• Publication Date: 2017-11
• Subjects: Spinothalamic tract -- Cordotomy -- Diffusion tensor imaging -- Pain; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2017.08.031
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Percutaneous radiofrequency cordotomy (PRFC) eliminates unilateral pain. Analgesia results from focal ablation of the lateral spinothalamic tract (STT). Study of PRFC mechanisms has been limited to postmortem histology. We studied a patient with successful PRFC using diffusion tensor imaging (DTI). DTI confirms that PRFC results in anterograde degeneration of the STT. Abstract: The purpose of this study is to demonstrate the potential of diffusion tensor imaging (DTI) to reveal structural mechanisms underlying spinal ablative procedures, including percutaneous radiofrequency cordotomy (PRFC). PRFC is a surgical procedure that produces analgesia through focal ablation of the lateral spinothalamic tract (STT), thereby interrupting the flow of pain information from the periphery to the brain. To date, studies regarding mechanisms of analgesia after PRFC have been limited to postmortem cadaveric dissection and histology. However, with recent advances in DTI, the opportunity has arisen to study the STT non-invasively in vivo . In this technical note, an individual with successful pain relief following unilateral STT PRFC was examined using DTI, with the contralateral STT serving as an internal control. PRFC substantially reduced rostrocaudal directional DTI signal in the STT from the lesion in the cervical spinal cord through the pons and mesencephalon. Our findings confirm that focal ablation and anterograde degeneration accompany the analgesic effects of PRFC. In vivo imaging of the STT with DTI may contribute to surgical targeting for PRFC procedures, better understanding of the therapeutic and untoward effects of PRFC, and a deeper understanding of spinothalamic contributions to nociception.