Chemical Constituents and Evaluation of Cytotoxic Activities of Curcuma zedoaria (Christm.) Roscoe Oils from Malaysia and Indonesia. Issue 4 (4th July 2017)

• Record Type: Journal Article
• Authors: Syamsir, Devi Rosmy; Sivasothy, Yasodha; Hazni, Hazrina; Abdul Malek, Sri Nurestri; Nagoor, Noor Hasima; Ibrahim, Halijah; Awang, Khalijah
• Is Part Of: Journal of essential oil-bearing plants. Volume 20:Issue 4(2017)
• Page Start: 972
• Page End: 982
• Publication Date: 2017-07-04
• Subjects: Curcuma zedoaria (Christm.) Roscoe -- essential oil -- cytotoxic effects -- MTT assay; Essences and essential oils -- Periodicals; Aromatic plants -- Biotechnology -- Periodicals; Oilseed plants -- Biotechnology -- Periodicals; Aromatic plants -- Periodicals; Oilseed plants -- Periodicals; 661.80605
• DOI: 10.1080/0972060X.2017.1362997
• Languages: English
• ISSNs: 0972-060X

Abstract

Abstract: The essential oils obtained by hydrodistillation of the rhizomes of Curcuma zedoaria (Christm.) Roscoe collected from Malaysia and Indonesia were analyzed by capillary GC and GC-MS. Both the oils were principally sesquiterpenic in nature and were characterized by zerumbone (17.14% and 12.07%, respectively). Camphor (17.56% and 19.69%, respectively) was also abundant in both oils. The cytotoxic effects of both the oils on human breast (MCF-7 and MDA-MB 231), lung (A549 and SK-LU-1) and cervical (HeLa S3 and SiHa) cancer cell lines were examined using the MTT assay. The Malaysian C. zedoaria rhizome oil was found to be cytotoxic against the MCF-7, SK-LU-1, HeLa S3 and SiHa cell lines, with IC50 values being less than 10 μg/mL. Our findings support the use of the Malaysian C. zedoaria rhizome oil as a potential chemopreventive agent towards a wide spectrum of cancer in particular cervical cancer.