Catalyst-free glycerol-mediated green synthesis of 5′-thioxospiro[indoline-3, 3′-[1, 2, 4]triazolidin]-2-ones/spiro[indoline-3, 3′-[1, 2, 4]triazolidine]-2, 5′-diones. Issue 21 (2nd November 2017)

• Record Type: Journal Article
• Authors: Tiwari, Jyoti; Saquib, Mohammad; Singh, Swastika; Tufail, Fatima; Singh, Jaya; Singh, Jagdamba
• Is Part Of: Synthetic communications. Volume 47:Issue 21(2017)
• Page Start: 1999
• Page End: 2006
• Publication Date: 2017-11-02
• Subjects: Catalyst free -- glycerol -- spiro[indoline-3, 3′-[1, 2, 4]triazolidine]-2, 5′-diones -- spirooxindoles -- thioxospiro[indoline-3, 3′-[1, 2, 4]triazolidin]-2-ones; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2017.1359844
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: The development of new catalyst-free green and efficient protocol to access 5′-thioxospiro[indoline-3, 3′-[1, 2, 4]triazolidin]-2-ones/spiro[indoline-3, 3′-[1, 2, 4]triazolidine]-2, 5′-diones, potential privileged scaffolds for drug discovery, is disclosed. Key feature of this methodology is the dual use of glycerol—a recyclable, bioorganic compound, as a solvent cum promoter. Other highlights include use of inexpensive reagents, mild reaction conditions, operational simplicity, short reaction time, no need for chromatographic purification, and high yields. GRAPHICAL ABSTRACT: