Changes in peripheral blood T-cell balance after percutaneous tumor ablation. Issue 6 (2nd November 2017)

• Record Type: Journal Article
• Authors: Takaki, Haruyuki; Imai, Naoko; Thomas, Contessa T.; Yamakado, Koichiro; Yarmohammadi, Hooman; Ziv, Etay; Srimathveeravalli, Govindarajan; Sofocleous, Constantinos T.; Solomon, Stephen B.; Erinjeri, Joseph P.
• Is Part Of: Minimally invasive therapy & allied technologies. Volume 26:Issue 6(2017)
• Page Start: 331
• Page End: 337
• Publication Date: 2017-11-02
• Subjects: Radiofrequency ablation -- microwave ablation -- cryoablation -- T-cell -- lymphocyte; Endoscopy -- Periodicals; Interventional radiology -- Periodicals; Endoscopic surgery -- Periodicals; 617.05
• DOI: 10.1080/13645706.2017.1310737
• Languages: English
• ISSNs: 1364-5706

Abstract

Abstract: Purpose: To evaluate the changes in T-cell balance in peripheral blood following percutaneous tumor ablation. Material and methods: Patients underwent thermal ablation including radiofrequency ( n = 9) and microwave ablation ( n = 5), or cryoablation ( n = 5). Target tumors were located in the lung ( n = 7), soft tissue ( n = 5), liver ( n = 4), and bone ( n = 3). Patient peripheral blood samples were collected before and within 14 days after ablation. Peripheral blood populations of cytotoxic T-cells (CTL), type-1 (Th 1) and type-2 helper T-cells (Th 2), and regulatory T-cells (Treg ) were measured using flow cytometry. Changes in CTL/Treg and Th 1/Th 2 ratios before and after ablation therapy were compared using paired t- tests. Results: Peripheral blood CTL population (27.5 ± 2.1% to 30.2 ± 2.5%, p < .03) and CTL/Treg ratios (18.8 ± 3.7% to 21.6 ± 3.6%, p < .05) increased significantly after ablation. Although a significant increase in CTL/Treg ratios was found after heat-based ablation (18.0 ± 4.4% to 21.6 ± 4.7%, p < .02), it remained unchanged after cryoablation (21.0 ± 7.0% to 21.5 ± 4.3%, p = .92). Th 1/Th 2 ratio (13.7 ± 3.0% to 17.2 ± 3.5%, p = .12) remained unchanged after ablation. Conclusion: Ablation therapy alters the T-cell balance by increasing the systemic CTL/Treg, ratio. Heat-based ablation might be a more effective approach than cryoablation to enhance systemic anti-tumor immunity.