The relationship of single-strand breaks in DNA to breast cancer risk and to tissue concentrations of oestrogens. (3rd October 2017)

• Record Type: Journal Article
• Authors: Sahadevan, Mathavi; Lee, Oukseub; Muzzio, Miguel; Phan, Belinda; Jacobs, Lisa; Khouri, Nagi; Wang, Jun; Hu, Hong; Stearns, Vered; Chatterton, Robert T.
• Is Part Of: Biomarkers. Volume 22:Number 7(2017)
• Page Start: 689
• Page End: 697
• Publication Date: 2017-10-03
• Subjects: Breast cancer -- single-strand breaks in DNA -- breast cancer risk -- tissue oestrogens -- DNA methylation; Biochemical markers -- Periodicals; 610.28
• DOI: 10.1080/1354750X.2017.1293736
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Context: Clinical study of breast cancer patients in Chicago, IL, USA. Objective: Ascertain the utility of measurements of single-strand breaks (SSB) in DNA for assessment of breast cancer risk. Methods: Fine-needle aspirates of the breast, SSB by nick translation, percent breast density (PBD), Gail model risk, cumulative methylation index (CMI), enzymes of DNA repair and tissue antioxidants. Results: DNA repair enzymes and 4-hydroxyestradiol were negatively associated with SSB; CMI and PBD were positively associated. Conclusions: Quantitative measurement of SSBs by this procedure indicates the relative number of SSBs and is related to promoter methylation, antioxidant availability and percent breast density.