Arylative Cyclization of Indole‐1‐carboxamides with 1, 6‐Enynes for the Synthesis of Polycyclic Indole Scaffolds. Issue 38 (11th October 2017)

• Record Type: Journal Article
• Authors: Reddy, Chatrala Ravikumar; Yarlagadda, Suresh; Sridhar, Balasubramanian; Reddy, Basi V. Subba
• Is Part Of: European journal of organic chemistry. Issue 38(2017)
• Page Start: 5763
• Page End: 5768
• Publication Date: 2017-10-11
• Subjects: Synthetic methods -- Nitrogen heterocycles -- Annulation -- Michael addition -- Transition‐metal catalysis -- Polycycles; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201701029
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : A new alkyne annulation strategy has been developed for the synthesis of polycyclic indole derivatives through a cascade of C–H annulation and Michael addition reactions. This is the first report on sequential alkyne annulation and aza‐Michael addition reactions of indole‐1‐carboxamides with alkyne tethered substrates. Abstract : A facile synthesis of polycyclic indole derivatives is reported through a sequential C–C and C–N bond formation using transition metal catalysis.