Cyclometalated Rhodium(III) Complexes Based on Substituted 2‐Phenylpyridine Ligands: Synthesis, Structures, Photophysics, Electrochemistry, and DNA‐Binding Properties. Issue 36 (8th August 2017)

• Record Type: Journal Article
• Authors: Liang, Haoran; Hao, Taotao; Yin, Changzhen; Yang, Xi; Fu, Haiyan; Zheng, Xueli; Li, Ruixiang; Xiao, Dan; Chen, Hua
• Is Part Of: European journal of inorganic chemistry. Issue 36(2017)
• Page Start: 4149
• Page End: 4157
• Publication Date: 2017-08-08
• Subjects: Rhodium -- Biological activity -- Photophysics -- Electrochemistry -- CT DNA; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201700700
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : A new series of octahedral rhodium(III) complexes1 –8 of the type [(L n )2 Rh(dppz)]Cl ( n = 1–6) and [(L n )2 Rh(dppz)](PF6 ) { n = 1, 7, 8; L = 2‐phenylpyridine, with different modifications, as the C, N‐chelating ligand; and dppz = dipyrido[3, 2‐a:2′, 3′‐ c ]phenazine} have been synthesized and fully characterized. The photophysical properties of the complexes have been investigated. The single‐crystal X‐ray diffraction structures of five complexes – [(L1)2 Rh(dppz)](PF6 ), [(L2)2 Rh(dppz)]Cl, [(L3)2 Rh(dppz)](PF6 ), [(L4)2 Rh(dppz)](PF6 ), and [(L8)2 Rh(dppz)](PF6 ) – have confirmed the anticipated structure and have revealed the effect of substitution on the structure of the complex, which has been reasonably explained through experimental electrochemical characterization. The interaction of complexes1 –8 with calf thymus DNA (CT DNA) has been verified by the fluorescent detection of ethidium bromide (EB) displacement studies. The result clearly suggests that the DNA‐binding abilities of these Rh complexes are not only influenced by the DNA‐intercalator dppz, but are also highly influenced by the electronic and steric properties of the C, N‐chelating ligands. Abstract : Eight new octahedral rhodium(III) complexes have been reported. The photophysical and electrochemical properties, as well as the DNA‐binding properties, of all of the complexes were investigated. This provides useful information for studying the design of transition‐metal complexes with biological activities.