Pharmacokinetics of meloxicam in mature swine after intravenous and oral administration. Issue 3 (1st October 2014)

• Record Type: Journal Article
• Authors: Pairis‐Garcia, M. D.; Johnson, A. K.; KuKanich, B.; Wulf, L.; Millman, S. T.; Stalder, K. J.; Karriker, L. A.; Coetzee, J. F.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 38:Issue 3(2015)
• Page Start: 265
• Page End: 270
• Publication Date: 2014-10-01
• Subjects: Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12170
• Languages: English
• ISSNs: 0140-7783

Abstract

Abstract : The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (i.v.) and oral (p.o.) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3 ± 65.68 kg) were administered an i.v. or p.o. dose of meloxicam at a target dose of 0.5 mg/kg in a cross‐over design. Plasma samples collected up to 48 h postadministration were analyzed by high‐pressure liquid chromatography and mass spectrometry (HPLC‐MS) followed by noncompartmental pharmacokinetic analysis. Mean peak plasma concentration (CMAX ) after p.o. administration was 1070 ng/mL (645–1749 ng/mL). TMAX was recorded at 2.40 h (0.50–12.00 h) after p.o. administration. Half‐life (T½ λ z ) for i.v. and p.o. administration was 6.15 h (4.39–7.79 h) and 6.83 h (5.18–9.63 h), respectively. The bioavailability (F) for p.o. administration was 87% (39–351%). The results of this study suggest that meloxicam is well absorbed after oral administration.