AgOTf-catalyzed sequential synthesis of 4-isoquinolones via oxidative ring opening of aziridines and aza-Michael addition. Issue 39 (21st September 2017)

• Record Type: Journal Article
• Authors: Xing, Siyang; Cui, Hong; Gu, Nan; Li, Ying; Wang, Kui; Tian, Dawei; Qin, Jiajing; Liu, Qiaoyang
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 39(2017)
• Page Start: 8308
• Page End: 8312
• Publication Date: 2017-09-21
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02167d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An efficient AgOTf-catalyzed sequential reaction involving the oxidative ring-opening of aziridines by DMSO and aza-Michael addition has been developed. Abstract : An efficient AgOTf-catalyzed sequential reaction involving the oxidative ring-opening of aziridines by DMSO and aza-Michael addition has been developed. A series of 2, 3-dihydro-4(1 H )-isoquinolones were afforded in moderate to good yields by the formation of one new CO bond and one new C–N bond. The features of this sequential reaction include high bonding efficiency, use of a catalytic amount of catalysts, a broad substrate scope and mild conditions. This methodology provides a good choice for constructing the libraries of 2, 3-dihydro-4(1 H )-isoquinolones.