Frontispiece: Multivalency Increases the Binding Strength of RGD Peptidomimetic‐Paclitaxel Conjugates to Integrin αVβ3. Issue 58 (17th October 2017)

• Record Type: Journal Article
• Authors: Raposo Moreira Dias, André; Pina, Arianna; Dal Corso, Alberto; Arosio, Daniela; Belvisi, Laura; Pignataro, Luca; Caruso, Michele; Gennari, Cesare
• Is Part Of: Chemistry. Volume 23:Issue 58(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-10-17
• Subjects: antitumor agents -- click chemistry -- integrins -- multivalency -- peptidomimetics; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201785863
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Multivalent binding is often used to increase the strength of ligand–receptor interactions. In oncology, the development of multimeric conjugates aims at promoting a more efficient recognition of target antigens, possibly leading to better therapeutic performance. The affinity for integrin αV β3 of multimeric conjugates ( cyclo [DKP‐RGD]) n ‐Val‐Ala‐PTX ( n =1–4) increases with the number of cyclo [DKP‐RGD] ligands up to n =3. For more information, see the Communication by L. Pignataro, C. Gennari et al. onpage 14410 ff.