Frontispiece: From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane. Issue 58 (17th October 2017)

• Record Type: Journal Article
• Authors: Mizuno, Akira; Matsui, Kouhei; Shuto, Satoshi
• Is Part Of: Chemistry. Volume 23:Issue 58(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-10-17
• Subjects: conformational restriction -- cyclopropane -- membrane permeability -- peptidomimetics -- three-dimensional structural diversity; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201785862
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : The use of cyclopropane in peptidomimetic chemistry, focusing on the importance of 3D structural diversity for effective lead identification, is the subject of the Minireview by Shuto et al. onpage 14394 ff. Cyclopropane, the smallest carbon ring, is an irreplaceable tool for medicinal chemists to regulate the conformation of molecules in a three‐dimensionally diverse manner because of its characteristic structural features. Accordingly, the library of conformationally restricted peptidomimetics based on cyclopropane produces suitable leads mimicking key conformations of the parent peptides.