Α‐Glucosidase Inhibitory Xanthones from the Roots of Garcinia fusca. Issue 10 (27th September 2017)

• Record Type: Journal Article
• Authors: Nguyen, Nam K.; Truong, Xuyen A.; Bui, Thai Q.; Bui, Dzung N.; Nguyen, Hai X.; Tran, Phuong T.; Nguyen, Lien‐Hoa D.
• Is Part Of: Chemistry & biodiversity. Volume 14:Issue 10(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-09-27
• Subjects: Garcinia fusca -- Xanthones -- Fuscaxanthones J and K -- α‐Glucosidase inhibitory activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201700232
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract : Two new compounds, fuscaxanthones J (1 ) and K (2 ), together with eight known xanthones (3 –10 ) were isolated from an ethyl acetate extract of the roots of Garcinia fusca . Their structures were determined using spectroscopic methods, mainly 1D‐ and 2D‐NMR. α ‐Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J (1 ) showed the most significant effect with an IC 50 value of 8.3 ± 1.8 μm (compared with acarbose, IC 50 = 214.5 ± 2.3 μm ). Abstract :