The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma. (4th July 2017)

• Record Type: Journal Article
• Authors: Topic, Aleksandra; Francuski, Djordje; Nikolic, Aleksandra; Milosevic, Katarina; Jovicic, Snezana; Markovic, Bojan; Djukic, Mirjana; Radojkovic, Dragica
• Is Part Of: Fetal and pediatric pathology. Volume 36:Number 4(2017)
• Page Start: 294
• Page End: 303
• Publication Date: 2017-07-04
• Subjects: 8-oxodG -- superoxide dismutase -- myeloperoxidase -- childhood asthma -- eczema; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2017.1315199
• Languages: English
• ISSNs: 1551-3815

Abstract

ABSTRACT: Introduction : The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. Materials and Methods : The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7, 8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu, Zn- superoxide dismutase (Cu, Zn-SOD) in serum. Results : Logistic regression analysis revealed that female gender, tobacco smoke exposure, and increased 8-oxodG/creatinine were associated with risk for intermittent asthma, while the positive allergy test and increased Cu, Zn-SOD were associated with eczema in asthmatic children. Higher MPO ( p = 0.033), and percent of granulocytes ( p = 0.030) were found in severe persistent asthma in comparison to intermittent or mild persistent asthma. Conclusion : The main findings that TSE-induced oxidative stress is a risk for intermittent asthma and eczema may be clinically significant for the disease prevention and therapeutic improvements.