Angiotensin-Converting Enzyme Gene Polymorphism in Children with Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings. (4th July 2017)

• Record Type: Journal Article
• Authors: Monajemzadeh, Maryam; Hesami, Mahshid; Shahsiah, Reza; Vasei, Mohammad; Hooshmand, Safoora; Tanzifi, Parin; Hajizadeh, Niloofar; Ataei, Neamatollah; Mehrkash, Mehryar; Javadi Larijani, Faezeh; Moghtaderi, Mastaneh; Bazargani, Behnaz; Khorvash, Reza; Soleimanifar, Narjes
• Is Part Of: Fetal and pediatric pathology. Volume 36:Number 4(2017)
• Page Start: 265
• Page End: 275
• Publication Date: 2017-07-04
• Subjects: Angiotensin converting enzyme -- ACE I/D gene polymorphism -- idiopathic nephrotic syndrome -- real time PCR; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2017.1287229
• Languages: English
• ISSNs: 1551-3815

Abstract

ABSTRACT: Objective: Angiotensin converting enzyme (ACE) converts angiotensin I into angiotensin II. The ACE gene shows an I/D polymorphism, which correlates with ACE concentrations. The aim of this study is to evaluate the distribution of the ACE I/D genotype in children with idiopathic nephrotic syndrome (INS) and healthy controls and study the effect of this polymorphism on clinical and pathologic findings. Methods: ACE gene I/D polymorphism of 104 patients with INS and 119 controls were determined. Results: The DD, ID, and II genotypes were found in 58.7%, 22.1%, and 19.2% of the patients, and in 79.8%, 2.5%, and 17.6% of controls, respectively ( p > 0.05). The ID genotype was seen more frequently in patients resistant to treatment. Conclusion: The observed differences with previous reports suggest the influence of the genetic background on disease course. The ACE I/D gene polymorphism's role seems to be more important in renal disease progression than susceptibility.