Three‐period, two‐treatment crossover design under long‐term carryover effect. (26th May 2017)

• Record Type: Journal Article
• Authors: Chatterjee, Suryasish; Bandyopadhyay, Uttam
• Is Part Of: Statistica Neerlandica. Volume 71:Number 4(2017)
• Page Start: 263
• Page End: 285
• Publication Date: 2017-05-26
• Subjects: asymptotic distribution -- asymptotic power -- asymptotic relative efficiency -- asymptotically distribution free -- carryover effect -- crossover design -- exactly distribution free -- parallel group design.AMS classification: primary 62G10: secondary 62L05; Statistics -- Periodicals; 519.5; 314.92
• DOI: 10.1111/stan.12110
• Languages: English
• ISSNs: 0039-0402

Abstract

Abstract : The paper describes non‐parametric approach for analysis of a three‐period, two‐treatment, four‐sequence crossover design in which test procedure for interchangeability of the treatment effects is obtained. The proposed procedure is based on a non‐parametric model, which incorporates, along with the direct treatment effects and the usual carryover effects, the long‐term carryover effects. Relevant competitors are obtained. Related asymptotic results are given. By performing simulation study, we compared the procedures with respect to type I error rate and power. Furthermore, confidence intervals for treatment differences are studied. The procedures are illustrated with a data study.