Association between SNCA rs2736990 polymorphism and Parkinson's disease: a meta-analysis. (29th September 2017)

• Record Type: Journal Article
• Authors: Fang, Jinni; Hou, Binghui; Liu, Hongxin; Zhang, Xiaona; Wang, Jing; Zhou, Chang; Xie, Anmu
• Is Part Of: Neuroscience letters. Volume 658(2017)
• Page Start: 102
• Page End: 107
• Publication Date: 2017-09-29
• Subjects: SNCA rs2736990 gene polymorphism -- Parkinson's disease -- Meta-analysis; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.08.051
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: SNCA rs2736990 polymorphism and Parkinson's disease by meta-analysis. The T allele, TT and TC genotype of rs2736990(C/T) polymorphism may decrease the risk of PD. The rs12456492(A/G) polymorphism was associated with the risk of PD in all genetic models. Abstract: Emerging evidence suggests that the SNP rs2736990 of SNCA is a susceptibility factor for idiopathic Parkinson's disease (PD) in different populations, but the studies which examined the association have provided inconsistent results. Therefore, we performed a meta-analysis of some case-control studies to obtain a more exact estimation of there associations. All the relevant studies were extracted from PubMed, Embase, EBSCO, Chineses national knowledge infrastructure, Google Scholar and Wanfang databases (up to February 2017). A total of six studies with 2525 PD cases and 2165 controls were eventually enrolled in the present meta-analysis based on the strict inclusion and exclusion criteria. The pooled analysis showed that there is a significant association between rs2736990 polymorphism and PD susceptibility in all genetic models (T vs. C: OR = 0.772, 95%CI: 0.709–0.840, P = 0.001; TT vs. CC: OR = 0.586, 95%CI: 0.490–0.701, P = 0.001; TC vs. CC: OR = 0.814, 95%CI: 0.716–0.925, P = 0.002; TT+TC vs. CC: OR = 0.752, 95%CI: 0.666–0.848, P = 0.001; TT vs. TC+CC: OR = 0.658, 95%CI: 0.561–0.772, P = 0.001). Our meta-analysis provides evidence that the T allele, TT and TC genotype of rs2736990(C/T) polymorphism may decrease the risk of PD.