Epileptic interictal discharges are more frequent during NREM slow wave downstates. (29th September 2017)

• Record Type: Journal Article
• Authors: Ujma, Péter Przemyslaw; Halász, Péter; Kelemen, Anna; Fabó, Dániel; Erőss, Loránd
• Is Part Of: Neuroscience letters. Volume 658(2017)
• Page Start: 37
• Page End: 42
• Publication Date: 2017-09-29
• Subjects: Epilepsy -- Interictal discharge -- Slow wave -- NREM sleep -- EEG; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2017.08.020
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: NREM EEG phenomena are associated with interictal discharges (IIDs) in epilepsy. The relationship between IIDs and SW (slow wave) synchronization was investigated. IIDs occurred more often during SW downstates and larger waves. No association between SW slope, EEG synchronization and IID occurrence was found. Abstract: Epileptiform activity in various but not all epilepsy and recording types and cerebral areas is more frequent in NREM sleep, and especially during sleep periods with high-amplitude EEG slow waves. Slow waves synchronize high-frequency oscillations: physiological activity from the theta through the gamma band usually appears during scalp-positive upstates while epileptiform activity occurs at transitory phases and the scalp-negative downstate. It has been proposed that interictal discharges (IIDs) are facilitated by the high degree of neuronal firing synchrony during slow wave transitory and downstates. This would suggest that their occurrence increases as a function of slow wave synchronization, indicated by greater amplitude, steeper slopes and higher EEG signal synchronization. We investigated the occurrence of IIDs during NREM sleep slow waves in epileptic patients undergoing presurgical electrophysiological monitoring. Intracranially registered IIDs preferentially occurred during the scalp-negative downstates of frontal scalp slow waves in all subjects. IID occurrence was more frequent during larger slow waves in the pooled sample and a subset of subjects. However, slow wave slope steepness and EEG signal synchronization between two frontal scalp channels was not significantly associated with IID occurrence. Our results indicate that IIDs indeed do not occur at the same slow wave phase as physiological rhythms, but contrary to previous hypotheses their occurrence is not strongly affected by EEG synchronization.