Carborane-linked 2′-deoxyuridine 5′-O-triphosphate as building block for polymerase synthesis of carborane-modified DNA. Issue 21 (1st November 2017)

• Record Type: Journal Article
• Authors: Balintová, Jana; Simonova, Anna; Białek-Pietras, Magdalena; Olejniczak, Agnieszka; Lesnikowski, Zbigniew J.; Hocek, Michal
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 27:Issue 21(2017)
• Page Start: 4786
• Page End: 4788
• Publication Date: 2017-11-01
• Subjects: Nucleotides -- Nucleoside triphosphates -- Carboranes -- DNA polymerase -- Oligonucleotides; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2017.09.064
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: p -Carborane-linked dUTP was synthesized and used as a substrate in polymerase catalyzed enzymatic synthesis of carborane-modified DNA (with up to 21 carborane units). Abstract: 5-[( p -Carborane-2-yl)ethynyl]-2′-deoxyuridine 5′- O -triphosphate was synthesized and used as a good substrate in enzymatic construction of carborane-modified DNA or oligonucleotides containing up to 21 carborane moieties in primer extension reactions by DNA polymerases.