New cytotoxic furan from the marine sediment-derived fungi Aspergillus niger. Issue 22 (17th November 2017)

• Record Type: Journal Article
• Authors: Uchoa, Paula Karina S.; Pimenta, Antonia T. A.; Braz-Filho, Raimundo; de Oliveira, Maria da Conceição F.; Saraiva, Natália N.; Rodrigues, Barbara S. F.; Pfenning, Ludwig H.; Abreu, Lucas M.; Wilke, Diego V.; Florêncio, Katharine G. D.; Lima, Mary Anne S.
• Is Part Of: Natural product research. Volume 31:Issue 22(2017)
• Page Start: 2599
• Page End: 2603
• Publication Date: 2017-11-17
• Subjects: Marine-derived fungi -- Aspergillus niger -- furan derivative -- cytotoxic activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1283499
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A fungal strain of Aspergillus niger was recovered from sediments collected in the Northeast coast of Brazil (Pecém's offshore port terminal). Cultivation in different growth media yielded a new ester furan derivative, 1, along with malformin A1, malformin C, cyclo ( trans -4-hydroxy-L-Pro-L-Leu), cyclo ( trans -4-hydroxy-L-Pro-L-Phe), cyclo (L-Pro-L-Leu), cyclo (L-Pro-L-Phe), pseurotin D, pseurotin A, chlovalicin, cyclo (L-Pro-L-Tyr) and cyclo (L-Pro-L-Val). Compound1 was cytotoxic against HCT-116 cell line, showing IC50 = 2.9 μg/mL (CI 95% from 1.8 to 4.7 μg/mL). Abstract :