In vitro cholinesterase inhibitory activity of some plants used in Iranian traditional medicine. Issue 22 (17th November 2017)

• Record Type: Journal Article
• Authors: Saeedi, Mina; Babaie, Khatereh; Karimpour-Razkenari, Elahe; Vazirian, Mahdi; Akbarzadeh, Tahmineh; Khanavi, Mahnaz; Hajimahmoodi, Mannan; Shams Ardekani, Mohammad Reza
• Is Part Of: Natural product research. Volume 31:Issue 22(2017)
• Page Start: 2690
• Page End: 2694
• Publication Date: 2017-11-17
• Subjects: Cholinesterase inhibitors -- Iranian traditional medicine -- A. catechu -- S. aromaticum -- C. chinensis -- P. vulgare -- I. turpethum; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1290620
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: In this study, in vitro evaluation of cholinesterase inhibitory (ChEI) activity of various plants including betel nuts ( Areca catechu L.), clove buds ( Syzygium aromaticum L . ), aerial parts of dodder ( Cuscuta chinensis Lam.), common polypody rhizomes ( Polypodium vulgare L.) and turpeth roots ( Ipomoea turpethum R. Br.) which were recommended for the treatment of AD symptoms in Iranian Traditional Medicine (ITM) is reported. Among them, aqueous extract of A. catechu L. was found as the most potent anti-AChE (IC50 = 32.00 μg/mL) and anti-BChE (IC50 = 48.81 ± 0.1200 μg/mL) agent. Abstract : Aqueous extract of betel nuts as AChE inhibitor (IC50 = 32.00 µg/mL).