A new antibacterial chromone derivative from mangrove-derived fungus Penicillium aculeatum (No. 9EB). Issue 22 (17th November 2017)

• Record Type: Journal Article
• Authors: Huang, Huarong; Liu, Ting; Wu, Xiaoen; Guo, Junxi; Lan, Xiong; Zhu, Qin; Zheng, Xi; Zhang, Kun
• Is Part Of: Natural product research. Volume 31:Issue 22(2017)
• Page Start: 2593
• Page End: 2598
• Publication Date: 2017-11-17
• Subjects: Chromone derivative -- Penicillium sp -- mangrove-derived fungus -- antibacterial activity -- α-glucosidase inhibition; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1283498
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new chromone derivative, (2ʹ S* )-2-(2ʹ-hydroxypropyl)-5-methyl-7, 8-dihydroxy-chromone (1 ), together with three known compounds, bacillisporin A (2 ), bacillisporin B (3 ) and 5-carboxyphthalide (4 ) were obtained from the mangrove-derived fungus Penicillium aculeatum (No. 9EB). Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds2 and3 exhibited potent inhibitory activity against Bacillus subtilis with the same MIC values of 0.13 ± 0.02 μM, whereas compound1 showed antibacterial activity against Salmonell with an MIC value of 2.00 ± 0.02 μM. Compound2 and3 possessed significant inhibitory activity against α -glucosidase with IC50 values of 33.55 ± 0.63 and 95.81 ± 1.12 μM, respectively. Abstract :