Androgen status in non-diabetic elderly men with heart failure. (2nd October 2017)

• Record Type: Journal Article
• Authors: Loncar, Goran; Bozic, Biljana; Neskovic, Aleksandar N.; Cvetinovic, Natasa; Lainscak, Mitja; Prodanovic, Nenad; Dungen, Hans-Dirk; von Haehling, Stephan; Radojicic, Zoran; Trippel, Tobias; Putnikovic, Biljana; Markovic-Nikolic, Natasa; Popovic, Vera
• Is Part Of: Aging male. Volume 20:Number 4(2017:Dec.)
• Page Start: 215
• Page End: 224
• Publication Date: 2017-10-02
• Subjects: Testosterone -- heart failure -- men -- adipokines -- survival -- body composition; Aging -- Periodicals; Men -- Periodicals; Gerontology -- Periodicals; Men -- Health and hygiene -- Periodicals; Aging -- periodicals; Geriatric -- periodicals; Men -- periodicals; Aged -- periodicals; Aged, 80 and over -- periodicals; 612.67
• DOI: 10.1080/13685538.2017.1350155
• Languages: English
• ISSNs: 1368-5538

Abstract

Abstract: Purpose: We aimed at evaluating androgen status (serum testosterone [TT] and estimated free testosterone [eFT]) and its determinants in non-diabetic elderly men with heart failure (HF). Additionally, we investigated its associations with body composition and long-term survival. Methods: Seventy three non-diabetic men with HF and 20 healthy men aged over 55 years were studied. Echocardiography, 6-min walk test, grip strength, body composition measurement by DEXA method were performed. TT, sex hormone binding globulin, NT-proBNP, and adipokines (adiponectin and leptin) were measured. All-cause mortality was evaluated at six years of follow-up. Results: Androgen status (TT, eFT) was similar in elderly men with HF compared to healthy controls (4.79 ± 1.65 vs. 4.45 ± 1.68 ng/ml and 0.409 ± 0.277 vs. 0.350 ± 0.204 nmol/l, respectively). In HF patients, TT was positively associated with NT-proBNP ( r = 0.371, p = 0.001) and adiponectin levels ( r = 0.349, p = 0.002), while inverse association was noted with fat mass ( r = −0.413, p < 0.001). TT and eFT were independently determined by age, total fat mass and adiponectin levels in elderly men with HF ( p < 0.05 for all). Androgen status was not predictor for all-cause mortality at six years of follow-up. Conclusions: In non-diabetic men with HF, androgen status is not altered and is not predictive of long-term outcome.