Copper-catalyzed oxidative cross-coupling of α-aminocarbonyl compounds with primary amines toward 2-oxo-acetamidines. Issue 38 (14th September 2017)

• Record Type: Journal Article
• Authors: Chen, Chuang; Zhu, Menghua; Jiang, Lihui; Zeng, Zebing; Yi, Niannian; Xiang, Jiannan
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 38(2017)
• Page Start: 8134
• Page End: 8139
• Publication Date: 2017-09-14
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02012k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A general and mild method for the construction of a carbon–nitrogen bond via copper-catalyzed oxidative cross-coupling of amines with α-aminocarbonyl compounds was achieved. Abstract : A general and mild method for the construction of a carbon–nitrogen bond via copper-catalyzed oxidative cross-coupling of amines with α-aminocarbonyl compounds was achieved. Amines, either aliphatic primary amines, aromatic primary amines or secondary amines can be used as the starting materials. When R 2 was different from R 3, two isomers would be observed. Therefore, this reaction system has a broad substrate scope and provides a facile pathway for the synthesis of 2-oxo-acetamidines.