A cation-exchange controlled core–shell MnS@Bi2S3 theranostic platform for multimodal imaging guided radiation therapy with hyperthermia boost. Issue 38 (11th July 2017)

• Record Type: Journal Article
• Authors: Li, Yuhao; Sun, Yun; Cao, Tianye; Su, Qianqian; Li, Zili; Huang, Mingxian; Ouyang, Ruizhuo; Chang, Haizhou; Zhang, Shuping; Miao, Yuqing
• Is Part Of: Nanoscale. Volume 9:Issue 38(2017)
• Page Start: 14364
• Page End: 14375
• Publication Date: 2017-07-11
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c7nr02384g
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : A core–shell MnS@Bi2 S3 nanostructure was fabricated for tri-modal imaging including CT, MRI, and PA guided thermo-radio synergistic therapy. Abstract : Overtreatment as a crucial modern medicine issue needs to be urgently addressed. Theranostic agents supply a unique platform and integrate multiple diagnosis and therapies to deal with this issue. In this study, a core–shell MnS@Bi2 S3 nanostructure was fabricated via two step reactions for tri-modal imaging guided thermo-radio synergistic therapy. The mass ratio between the core and shell of the constructed MnS@Bi2 S3 can be precisely controlled via cation exchange reaction. After surface PEGylation, MnS@Bi2 S3 -PEG nanoparticles exhibited excellent aqueous medium dispersibility for bioapplications. Based on the r 1 and r 2 relaxivity obtained from the MnS core and the strong near-infrared absorption and X-ray attenuation abilities of the Bi2 S3 shell, the intratumoral injected MnS@Bi2 S3 -PEG can realize in vivo magnetic resonance, computer tomography, and photoacoustic tumor imaging under a single injection dose. Hyperthermia significantly boosts the efficacy of radiation therapy, showing synergistic tumor treatment efficacy. No obvious toxicity is monitored for the treated mice. Our study not only provides a new way to precisely construct the core–shell nanocomposite, but also presents a unique theranostic platform and unifies the solutions for the challenges related with high injection dose and overtreatment.