Therapeutic potential of mesenchymal stem cells for diabetes. (October 2017)

• Record Type: Journal Article
• Authors: Moreira, Alvaro; Kahlenberg, Samuel; Hornsby, Peter
• Is Part Of: Journal of molecular endocrinology. Volume 59:Number 3(2017)
• Page Start: R109
• Page End: R120
• Publication Date: 2017-10
• Subjects: mesenchymal stem cell -- tissue regeneration -- diabetes -- endocrine; Molecular endocrinology -- Periodicals; Endocrinology -- Periodicals; 616.407
• DOI: 10.1530/JME-17-0117
• Languages: English
• ISSNs: 0952-5041

Abstract

Abstract : Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and clinical evidence have substantiated the therapeutic benefit of MSCs in various medical conditions. Currently, MSCs are the most commonly used cell-based therapy in clinical trials because of their regenerative effects, ease of isolation and low immunogenicity. Experimental and clinical studies have provided promising results using MSCs to treat diabetes. This review will summarize the role of MSCs on tissue repair, provide emerging strategies to improve MSC function and describe how these processes translate to clinical treatments for diabetes.