Association between thyroid dysfunction and dysglycaemia: a prospective cohort study. Issue 11 (28th July 2017)

• Record Type: Journal Article
• Authors: Chang, C.‐H.; Yeh, Y.‐C.; Shih, S.‐R.; Lin, J.‐W.; Chuang, L.‐M.; Caffrey, J. L.; Tu, Y.‐K.
• Is Part Of: Diabetic medicine. Volume 34:Issue 11(2017)
• Page Start: 1584
• Page End: 1590
• Publication Date: 2017-07-28
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.13420
• Languages: English
• ISSNs: 0742-3071

Abstract

Abstract: Aims: To compare the incidence of hyperglycaemia among participants with low, elevated and normal serum thyroid‐stimulating hormone concentration, as well as the incidence of abnormal thyroid function test results among participants with normal blood glucose and those with hyperglycaemia. Methods: In a prospective study, a cohort of 72 003 participants with normal, low and elevated serum thyroid‐stimulating hormone concentration were followed from the study beginning to the first report of diabetes and prediabetes. A proportional hazards regression model was used to calculate the hazard ratios and 95% CIs for each outcome, adjusting for age, sex, education level, smoking, alcohol consumption and obesity. Analyses for the association between dysglycaemia and incident abnormal thyroid function test were also conducted. Results: During a median 2.6 year follow‐up, the incident rates for dysglycaemia, particularly prediabetes, were substantially higher in participants with elevated thyroid‐stimulating hormone concentrations at baseline, while the rates for participants with normal and low thyroid‐stimulating hormone were similar. After controlling for risk factors, participants with elevated thyroid‐stimulating hormone retained a 15% increase in risk of prediabetes (adjusted hazard ratio 1.15, 95% CI 1.04–1.26), but were not at greater risk of diabetes (adjusted hazard ratio 0.96, 95% CI 0.64–1.44). By contrast, participants with normal and low thyroid‐stimulating hormone concentrations had similar dysglycaemia risks. Participants with diabetes and prediabetes were not at greater risks of developing abnormal thyroid function test results when compared with participants with euglycaemia. Conclusions: People with elevated serum thyroid‐stimulating hormone concentration are at greater risk of developing prediabetes. Whether this includes a greater risk of developing frank diabetes may require an extended period of follow‐up to clarify. What's new?: Elevated serum thyroid‐stimulating hormone (TSH) concentration may be a risk marker for prediabetes incidence. By contrast, low serum TSH concentration did not appear to influence the risk of dysglycaemia. People with diabetes and prediabetes were at no greater risk of developing abnormal thyroid function test results when compared with people with euglycaemia.