A rare case of CD1a‐negative Langerhans cell histiocytosis of the central nervous system in a child. Issue 10 (1st September 2017)

• Record Type: Journal Article
• Authors: Powell, Priscilla; Vitug, Gaile; Castro‐Silva, Fernando; Ray, Anish
• Is Part Of: Clinical case reports. Volume 5:Issue 10(2017)
• Page Start: 1664
• Page End: 1667
• Publication Date: 2017-09-01
• Subjects: Basal ganglia -- CD1a -- dendritic cell disorder -- diabetes insipidus -- Langerhans cell histiocytosis -- S100; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.1136
• Languages: English
• ISSNs: 2050-0904

Abstract

Key Clinical Message: Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [ Blood, 126, 2015, 26 and N Engl J Med, 331, 1994, 154]. Abstract : Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [ Blood, 126, 2015, 26 and N Engl J Med, 331, 1994, 154].