[PP.30.14] TRADITIONAL RISK FACTORS AS ARTERIAL HYPERTENSION, OBESITY AND POLYMORPHISM C825T GENE BETA 3-SUBUNIT OF G PROTEIN AMONG YOUNG AND MIDDLE-AGED WOMEN WITH CORONARY ARTERY DISEASE. (September 2017)

• Record Type: Journal Article
• Authors: Leonova, I.; Feoktistova, V.; Boldueva, S.; Sirotkina, O.; Vavilova, T.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523992.04672.51
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: To evaluate the prevalence of risk factors in young and middle age women with CAD and to determine the role of polymorphism C825T gene beta 3-subunit of G protein (GNB3) in the development of disease. Design and method: Detection of allelic variants of the gene GNB3 S825T conducted in 121 young and middle age (52, 0 ± 0, 6 years) women with CAD. Reproductive function (RF) was preserved in 49 (40%) women Results: Arterial hypertension (AG) met in 109 (90%), obesity - in 65 (54%) patients. 43 (88%) women with preserved RF had AH, 28 (57%) - obesity. 66 (92%) menopause woman had AH, obesity had 37 (51%) (p > 0, 05). The frequency of gene polymorphism S825T GNB3 in hetero- or homozygous state in the presence of a history of AH: 50% and 50% for genotypes CC and CT + TT, respectively, without AH - 83% and 17% for genotypes CC and CT + TT, respectively (p < 0.05). In women with AH - 825T allele carriers of the gene GNB3 experienced significantly higher values of systolic (169 ± 2 and 179 ± 1 mm Hg for the genotypes CC and CT + TT, respectively, p < 0.01) and diastolic blood pressure (104 ± 2 and 112 ± 1 mm Hg for the genotypes CC and CT + TT, respectively, p < 0.001). There were differences in the distribution of allelic variants of the gene GNB3 S825T depending on the presence or absence of obesity in the general group. Among patients in menopause obesity was more common in carriers of genotypes CT and TT - 60% vs. CC - 34%. Conclusions: In young and middle age women with CAD - 825T allele carriers in hetero- or homozygous gene GNB3 hypertension is more common, and among women with hypertension have higher numbers of systolic and diastolic blood pressure. Moreover, with the onset of menopause 825T allele carriers of the gene GNB3 increases the likelihood of obesity in women with CAD.