[PP.30.09] KIF6 GENE POLYMORPHISM IS ASSOCIATED WITH ARTERIAL RESISTANCE AND ATHEROSCLEROSIS IN PATIENTS WITH HYPERTENSION. (September 2017)

• Record Type: Journal Article
• Authors: Minushkina, L.; Koroleva, O.; Selezneva, N.; Kochkina, M.; Nikitin, A.; Zateyshchikov, D.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523989.19919.81
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Aim of the study was to elucidate possible association of KIF6 gene Trp719Arg polymorphism with the changes of the arterial wall in patients with hypertension. Design and method: We included into study 120 patients with hypertension (58 (43.8%) men and 62 (56.2%) women). The average age of 63, 4 ± 13, 5 years. 20% of patients had type 2 diabetes, 37.5% smoked, 8.3% had a history of stroke, 25% - myocardial infarction. All patients underwent color duplex scanning of carotid arteries with measurement of the intima-media thickness (IMT). The stiffness of the arteries was evaluated by measuring the PWV on the segment of the carotid-femoral and carotid-radial artery. The study was performed on the automated computer system Complior Colson (France), per standard procedures. Polymorphic markers were identified by PCR-RFLP in real time. Results: The frequency distribution of genotypes of polymorphic marker Trp719Arg KIF6 gene in the studied group corresponds to the equation Hradi-Weinberg equilibrium and were as follows: Trp/Trp - 40.8%, Trp/Arg - 43.4%, Arg/Arg - 15, 8%. Carriers Arg / Arg genotype had a significantly greater IMT of carotid arteries compared to carriers of other genotypes as a right (0, 98 ± 0, 034 mm and 0, 85 ± 0, 027 mm respectively, p = 0.023) and left (0, 93 ± 0.023 mm and 0, 80 ± 0, 039 mm respectively, p = 0, 028. Carriers of the Arg/Arg genotype also had higher central aortic pulse pressure (50, 0 ± 2, 19 mm Hg vs 42, 2 ± 3.21 mm Hg, p = 0, 032) and carotid-femoral PWV (13, 21 ± 0.561 m/s vs 9, 56 ± 0, 896 m/s, p = 0, 048) compared to carriers of other genotypes. Conclusions: Thus, we identified association of Arg/Arg genotype of KIF6 gene Trp719Arg polymorphism with an increase in the IMT of the carotid arteries and presents of arterial stiffness.