[PP.25.16] THE INFLAMMATORY STATUS SCORE INCLUDING TNF-ALPHA, IL-6, IL-8, IL-10, LEPTIN AND ADIPONECTIN IS ASSOCIATED WITH RESISTANT HYPERTENSION. (September 2017) - De Faria, A.
Abstract : Objective: Subclinical systemic inflammation has been indicated to be present in resistant hypertension (RHTN). The aim of the study was to develop an integrated measure of the circulating cytokines/adipokines that underlie the pathophysiology of RHTN. Design and method: RHTN (n = 112) and mild to moderate hypertensive (HTN) subjects (n = 112) were studied in a cross-sectional design. Plasma cytokine/adipokine [TNF-alpha, IL-6, IL-8, IL-10, leptin and adiponectin] values were divided into tertiles. A score ranging from 1 (lowest tertile) to 3 (highest tertile) was assigned. The inflammatory score (IS) was the sum of each pro-inflammatory cytokine score from which adiponectin and IL-10 – anti-inflammatory cytokines – scores were subtracted in each study subject. Results: IS was higher in RHTN subjects compared to their counterparts (4.2 ± 2.2 vs. 3.5 ± 1.9; p = 0.02). IS positively correlated with obesity parameters, such as body mass index (r = 0.40; p < 0.001), waist circumference (r = 0.30; p < 0.001) and fat mass assessed by bioimpedance (r = 0.31; p < 0.001) in all subjects. Logistic regression analyses revealed that IS was an independent predictor of RHTN (OR = 1.19; p = 0.02), apart from age, gender and race, although it did not remain significant after BMI adjustment. Conclusions: A state of subclinical inflammation defined by IS including TNF-alpha, IL-6, IL-8, IL-10, leptin and adiponectin is associated with RHTN. In addition, this score strongly correlates with obesity parameters, independently of hypertensive status. This integrated measure may represent a new tool for the evaluation of the severity of low-grade inflammation in order to identify RHTN patients; also highlights the contribution of obesity to inflammatory process.