[PP.26.12] 24HOUR SYSTOLIC BLOOD PRESSURE VS CLINIC SYSTOLIC BLOOD PRESSURE: WHICH CAN PREDICT BETTER EARLY VASCULAR AGING?. (September 2017)

• Record Type: Journal Article
• Authors: Antza, C.; Doundoulakis, I.; Stabouli, S.; Kotsis, V.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523910.54946.63
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: The aim of this study was to investigate which way of measuring blood pressure, clinic or 24h-ABPM, can predict better early vascular aging. Design and method: 278 consecutive subjects (47.5% male) aged 47.1 ± 22.9 years were included in the study. Subjects were never treated before for hypertension. All subjects underwent 24h-ABPM on a usual working day. Pulse wave velocity (PWV) was measured after 15 minutes of rest in the supine position. PWV was calculated as the transit time of the arterial pulse along the carotid-femoral distance divided with the distance measured directly and modified according the guidelines. Early vascular aging (EVA) was calculated using the age and the PWV values, according the guidelines. Results: In the univariate analysis, EVA was correlated with clinic SBP and 24 hour average of SBP (p < 0.001 for both). From ROC curves for EVA, AUC of 24-ABPM (0.723, p < 0.001) was larger than that of clinic SBP (0.692, p < 0.001). Multivariate analysis revealed that 24 hour average of SBP (p < 0.01), but not clinic SBP, independently predicted the outcome after adjustment for age, gender, BMI, LDL levels, e-GFR and clinic SBP. Conclusions: The 24 hour average of SBP can be a predictor of early vascular aging. This result shows the importance of 24h-ABPM compared to clinic blood pressure measurement in order to identify high risk patients.