[PP.17.12] LONG TERM VARIATIONS OF CREATININE IN ESSENTIAL HYPERTENSIVES. (September 2017)
- Record Type:
- Journal Article
- Title:
- [PP.17.12] LONG TERM VARIATIONS OF CREATININE IN ESSENTIAL HYPERTENSIVES. (September 2017)
- Main Title:
- [PP.17.12] LONG TERM VARIATIONS OF CREATININE IN ESSENTIAL HYPERTENSIVES
- Authors:
- Gosse, P.
Cremer, A.
Boulestreau, R.
Gaillard, P.
Papaioanou, G.
Lainé, M. - Abstract:
- Abstract : Objective: The way renal function may decline with time in benign essential hypertension is still a matter of debate. This evolution was studied in a prospective registry of essential hypertensive patients untreated at baseline and then treated with various antihypertensive treatments. Design and method: Among a registry of 1200 essential hypertensives, we selected all patients with baseline normal renal function (eGFR MDRD> = 60 ml/min/1.73m 2 ), no diabetes and no proteinuria and with at least one other creatinine dosage available at least 10 years apart from baseline. Results: 433 patients were thus selected (231 males, 202 females, aged 51 ± 11 years at inclusion with baseline creatinine = 83 ± 15 μmoles/l and eGFR = 82 ± 15). Average follow up was 18 ± 5 years. Average creatinine change was not significant (0 ± 27). A creatinine level > = 130 μmoles/l was recorded in 12 patients (2.8%) with only one terminal renal failure and dialysis. 46 showed an increase in creatinine of at least 20 μ moles. In all cases but two this increase was abrupt from a dosage to another and not progressive along the whole survey. The figure illustrates the variation of creatinine levels in patients with a creatinine increase of at least 20 μmoles and at least 3 different creatinine measurements during follow up. Figure. No caption available. A stepwise discriminant analysis showed that baseline office pulse pressure (PP) (p = 0.003), age (p = 0.001) and baseline eGFR (p < 0.001),Abstract : Objective: The way renal function may decline with time in benign essential hypertension is still a matter of debate. This evolution was studied in a prospective registry of essential hypertensive patients untreated at baseline and then treated with various antihypertensive treatments. Design and method: Among a registry of 1200 essential hypertensives, we selected all patients with baseline normal renal function (eGFR MDRD> = 60 ml/min/1.73m 2 ), no diabetes and no proteinuria and with at least one other creatinine dosage available at least 10 years apart from baseline. Results: 433 patients were thus selected (231 males, 202 females, aged 51 ± 11 years at inclusion with baseline creatinine = 83 ± 15 μmoles/l and eGFR = 82 ± 15). Average follow up was 18 ± 5 years. Average creatinine change was not significant (0 ± 27). A creatinine level > = 130 μmoles/l was recorded in 12 patients (2.8%) with only one terminal renal failure and dialysis. 46 showed an increase in creatinine of at least 20 μ moles. In all cases but two this increase was abrupt from a dosage to another and not progressive along the whole survey. The figure illustrates the variation of creatinine levels in patients with a creatinine increase of at least 20 μmoles and at least 3 different creatinine measurements during follow up. Figure. No caption available. A stepwise discriminant analysis showed that baseline office pulse pressure (PP) (p = 0.003), age (p = 0.001) and baseline eGFR (p < 0.001), but not PP at follow up or survey lasting were significant predictors of such an increase in creatinine level. Conclusions: There is no systematic increase in creatinine levels in benign essential hypertensives. Around 10% of patients showed a creatinine increase of at least 20 micromoles during follow up but this increase was abrupt and not slowly progressive … (more)
- Is Part Of:
- Journal of hypertension. Volume 35(2017)Supplement 2
- Journal:
- Journal of hypertension
- Issue:
- Volume 35(2017)Supplement 2
- Issue Display:
- Volume 35, Issue 2 (2017)
- Year:
- 2017
- Volume:
- 35
- Issue:
- 2
- Issue Sort Value:
- 2017-0035-0002-0000
- Page Start:
- Page End:
- Publication Date:
- 2017-09
- Subjects:
- Hypertension -- Periodicals
Hypertension -- Periodicals
616.132005 - Journal URLs:
- http://firstsearch.oclc.org ↗
http://journals.lww.com/jhypertension/pages/default.aspx ↗
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=toc&D=yrovft&AN=00004872-000000000-00000 ↗
http://www.jhypertension.com/ ↗
http://journals.lww.com/pages/default.aspx ↗ - DOI:
- 10.1097/01.hjh.0000523654.90517.14 ↗
- Languages:
- English
- ISSNs:
- 1473-5598
- Deposit Type:
- Legaldeposit
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- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5004.510000
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