[PP.14.25] C-344T POLYMORPHISM GENE ALDOSTERONE SYNTHASE (CYP11B), SERUM ALDOSTERONE AND ASSOCIATION WITH ATRIAL FIBRILLATION IN METABOLIC SYNDROME PATIENTS. (September 2017)

• Record Type: Journal Article
• Authors: Ma, Yi; Ionin, V.; Ulitina, A.; Pchelina, S.; Bazhenova, E.; Zaslavskaya, E.; Belyaeva, O.; Berkovich, O.; Baranova, E.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523573.87358.ea
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Aldosterone synthase - enzyme involved in aldosterone synthesis. Metabolic syndrome (MetS) and hyperaldosteronism are risk factors for atrial fibrillation (AF). The objective of this study was to investigate the association of the promoter polymorphism C(-344)T in the aldosterone synthase gene (CYP11B2) and serum aldosterone with the risk of AF in metabolic syndrome population, we carried out a case-control study. Design and method: We carried out a case-control study of 290 subjects (163 patients with MetS: 75 with paroxysmal and permanent AF, 88 without AF and 127 controls), 110 males, 180 females, age 50, 1 ± 10, 2 years. The C(-344)T genotypes in the aldosterone synthase gene (CYP11B2) were determined by polymerase chain reaction-restriction fragment length polymorphism. Serum aldosterone concentration was determined by enzyme immunoassay. Results: Prevalence of T(-344)T genotype of CYP11B2 in metabolic patients was higher than in control group (p = 0, 04). Serum aldosterone concentration in MetS patients with AF and without this arrhythmia was higher than in healthy control (205, 4 [130, 0;293, 8], 167, 5 [90, 8;303, 2] and 117, 0 [80, 8;237, 7] pg/ml; p = 0, 0001 and p = 0, 04). Serum aldosterone levels in carriers of different genotypes C(-344)T CYP11B2 gene in metabolic syndrome patients with atrial fibrillation and without arrhythmia, in control groups did not differ (p > 0, 05). Conclusions: Metabolic syndrome with and without atrial fibrillation is characterized by high serum aldosterone level. Our results do not support the association of the aldosterone synthase C(-344)T functional gene variant and atrial fibrillation in metabolic syndrome patients.