Serum Vitamin D Levels in Patients with Acute Anterior Uveitis. (4th July 2017)

• Record Type: Journal Article
• Authors: Dadaci, Zeynep; Cetinkaya, Servet; Oncel Acir, Nursen; Oncel, Mufide; Borazan, Mehmet
• Is Part Of: Ocular immunology and inflammation. Volume 25:Number 4(2017)
• Page Start: 492
• Page End: 496
• Publication Date: 2017-07-04
• Subjects: Acute anterior uveitis -- immune system -- pathogenesis -- rheumatologic diseases -- vitamin D; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2016.1139735
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: Purpose : To evaluate serum 25-hydroxyvitamin D levels in patients with acute anterior uveitis (AAU). Methods : This observational case–control study involved 20 patients with AAU, and 20 consecutive, age and sex-matched healthy subjects without any ocular or systemic diseases. Serum 25-hydroxyvitamin D was quantified with electrochemiluminescence technique. Results : No significant differences were found between the groups with respect to age ( p = 0.185) and sex ( p = 0.465). Serum vitamin D levels of the subjects with AAU (mean 5.75 ± 4.50 ng/mL, median 4.00 ng/mL, range: 3.00–19.00 ng/mL) were significantly lower than the control group (mean 12.96 ± 5.89 ng/mL, median 11.00 ng/mL, range: 5.20–25.92 ng/mL) ( p <0.001). Conclusions : We found significantly low serum levels of vitamin D in patients with AAU, which suggest that vitamin D deficiency may play a role in the pathogenesis of anterior uveitis. Further studies are necessary to demonstrate the efficacy of vitamin D supplementation in the management of patients with anterior uveitis.