Probing Chiral Recognition of Enzyme Active Sites with Octahedral Iridium(III) Propeller Complexes. Issue 10 (5th March 2015)

• Record Type: Journal Article
• Authors: Göbel, Peter; Ritterbusch, Florian; Helms, Melanie; Bischof, Matthias; Harms, Klaus; Jung, Manfred; Meggers, Eric
• Is Part Of: European journal of inorganic chemistry. Issue 10(2015)
• Page Start: 1654
• Page End: 1659
• Publication Date: 2015-03-05
• Subjects: Enzyme inhibitors -- Iridium -- Chirality -- Molecular recognition -- Metal‐centered configuration; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201500087
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract: Chiral bis ‐cyclometalated octahedral organoiridium(III) complexes were designed to target different classes of enzymes, namely carbonic anhydrases, histone deacetylases, and serine proteases. The stereoselective non‐racemic synthesis of selected complexes was used to study the chiral discrimination of enzyme active sites for enantiomers of propeller‐type octahedral metal complexes. Cases for negligible, modest, and significant chiral discrimination in the interaction of iridium propeller complexes with enzyme active sites were identified. Abstract : Enzyme inhibiting chiral bis ‐cyclometalated organoiridium(III) complexes were designed to investigate the influence of the metal‐centered configuration.