Cyclisation To Form Small, Medium and Large Rings by Use of Catalysed and Uncatalysed Azide–Alkyne Cycloadditions (AACs). Issue 32 (15th August 2017)

• Record Type: Journal Article
• Authors: Barlow, Thomas M. A.; Tourwé, Dirk; Ballet, Steven
• Is Part Of: European journal of organic chemistry. Issue 32(2017)
• Page Start: 4678
• Page End: 4694
• Publication Date: 2017-08-15
• Subjects: Cyclization -- Macrocycles -- Click chemistry -- Dimerization -- Azides; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201700521
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : This microreview briefly summarises recent developments in cyclisation to afford small, medium and large rings (five to 30 members) by way of both catalysed and uncatalysed azide–alkyne cycloaddition (AAC). The standard AAC reactions – intramolecular Huisgen, CuAAC and RuAAC – are presented, as well as some of their contemporary variations. In addition, we present useful strategies for overcoming common problems encountered in these reactions. Abstract : This microreview briefly summarises recent developments in the cyclisation to form small, medium and large rings (five to 30 or more members) by way of both catalysed and uncatalysed azide–alkyne cycloaddition (AAC). In addition, we present useful strategies for overcoming common problems encountered in these reactions.