Modes of drug elimination and bioactive metabolites. Issue 9 (September 2017)

• Record Type: Journal Article
• Authors: Chillistone, Shruti; Hardman, Jonathan G.
• Is Part Of: Anaesthesia and intensive care medicine. Volume 18:Issue 9(2017:Sep.)
• Page Start: 458
• Page End: 461
• Publication Date: 2017-09
• Subjects: Clearance -- excretion -- metabolism -- pharmacokinetics; Anesthesiology -- Periodicals; Critical care medicine -- Periodicals; Anesthesia -- Periodicals; Intensive care -- Periodicals; Electronic journals; Periodicals; 617.9605
• DOI: 10.1016/j.mpaic.2017.06.005
• Languages: English
• ISSNs: 1472-0299

Abstract

Abstract: Drug elimination is the removal of active drug from the body. Metabolism takes place largely in the liver and produces water-soluble metabolites which can be excreted in the bile or urine. Metabolism may also produce active or toxic metabolites or a pharmacologically active drug from an inactive prodrug. Most volatile anaesthetics are excreted unchanged via the lungs. Drug elimination can be affected by factors such as first-pass metabolism, genetic variants and various disease processes. Knowledge of these processes will allow better prediction of pharmacokinetics in practice.