Dibrominated camphoric acid derived salen complexes: Synthesis, characterization and cytotoxic activity. (24th November 2017)

• Record Type: Journal Article
• Authors: Silva Serra, M. Elisa; Murtinho, Dina; da Rocha, Zênis N.; Pires, Ana Salomé; Baptista, João Gabriel; Abrantes, Ana Margarida; Laranjo, Mafalda; Casalta-Lopes, João Eduardo; Botelho, Maria Filomena; Pais, Alberto A.C.C.; Nunes, Sandra C.C.; Burrows, Hugh D.; Costa, Telma
• Is Part Of: Polyhedron. Volume 137(2017)
• Page Start: 147
• Page End: 156
• Publication Date: 2017-11-24
• Subjects: Metal complexes -- Halogenated salen ligands -- Cytotoxic activity -- Theoretical calculations -- Electrochemical studies; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2017.08.038
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: The Cu(II) complex of the dibrominated ligand ( 1R, 3S )- N, N′ -bis[5-bromosalicylidene]-1, 3-diamino-1, 2, 2-trimethylcyclopentane was synthesized and screened for in vitro cytotoxic activity against HCC1806 and MCF7 breast cancer and LS1034 and WiDr colon cancer cells lines. IC50 values of 0.95–2.32 μM were observed, constituting a marked improvement relative to current conventional chemotherapy. Abstract: Novel brominated salen metal complexes from ( 1R, 3S )- N, N′ -bis[5-bromosalicylidene]-1, 3-diamino-1, 2, 2-trimethylcyclopentane and Cu(II), Fe(III) and Mn(III) were synthesized and screened for their in vitro cytotoxic activity against two breast cancer cell lines, HCC1806 and MCF7, and two colon cancer cells lines, LS1034 and WiDr. Results show that the copper complex exhibits the highest cytotoxic activity towards all cell lines studied, presenting IC50 values of 0.95–2.32 μM. The anti-proliferative effect observed with the copper complex constitutes a marked improvement relative to current conventional chemotherapy. A relationship between the biological activity of the most efficient Cu(II) complex and its structure is established using theoretical calculations and electrochemical studies.