Association between muscle hydration measures acquired using bioelectrical impedance spectroscopy and magnetic resonance imaging in healthy and hemodialysis population. Issue 1 (27th January 2015)

• Record Type: Journal Article
• Authors: Sawant, Anuradha; House, Andrew A.; Chesworth, Bert M.; Connelly, Denise M.; Lindsay, Robert; Gati, Joe; Bartha, Robert; Overend, Tom J.
• Is Part Of: Physiological reports. Volume 3:Issue 1(2015:Jan.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-01-27
• Subjects: Apparent diffusion coefficient -- end‐stage renal disease -- hemodialysis -- skeletal muscle -- Transverse relaxation times; Physiology -- Periodicals; 571
• DOI: 10.14814/phy2.12219
• Languages: English
• ISSNs: 2051-817X

Abstract

Abstract: Establishing the effect of fluctuating extracellular fluid (ECF) volume on muscle strength in people with end‐stage renal disease (ESRD) on hemodialysis (HD) is essential, as inadequate hydration of the skeletal muscles impacts its strength and endurance. Bioelectrical impedance spectroscopy (BIS) has been a widely used method for estimating ECF volume of a limb or calf segment. Magnetic resonance imaging (MRI)‐acquired transverse relaxation times ( T 2 ) has also been used for estimating ECF volumes of individual skeletal muscles. The purpose of this study was to determine the association between T 2 (gold standard) of tibialis anterior (TA), medial (MG), and lateral gastrocnemius (LG), and soleus muscles and calf BIS ECF, in healthy and in people with ESRD/HD. Calf BIS and MRI measures were collected on two occasions before and after HD session in people with ESRD/HD and on a single occasion for the healthy participants. Linear regression analysis was used to establish the association between these measures. Thirty‐two healthy and 22 participants on HD were recruited. The association between T 2 of TA, LG, MG, and soleus muscles and ratio of calf BIS‐acquired ECF and intracellular fluids (ICF) were: TA: β = 0.30, P > 0.05; LG: β = 0.37, P = 0.035; MG: β = 0.43, P = 0.014; soleus: β = 0.60, P < 0.001. For the HD group, calf ECF was significantly associated with T 2 of TA ( β = 0.44, P = 0.042), and medial gastrocnemius ( β = 0.47, P = 0.027) following HD only. Hence BIS‐acquired measures cannot be used to measure ECF volumes of a single muscle in the ESRD/HD population; however, BIS could be utilized to estimate ratio of ECF: ICF in healthy population for the LG, MG, and soleus muscles. Abstract : e12219 This figure summarizes the process of estimating the transverse relaxation time constants of a region of interest of tibialis anterior muscle before and after hemodialysis of a participant (computed using OsiriX 5.8.2 for Mac). Three small regions of interest were selected with care to avoid visible fatty tissue or muscle septum. The values of the three values thus generated were then averaged to estimate the representative transverse relation time constant for that muscle.