Semiquantifiable angiogenesis parameters in association with the malignant transformation of oral leukoplakia. (7th February 2017)

• Record Type: Journal Article
• Authors: Thiem, Daniel G. E.; Schneider, Schamiem; Venkatraman, Narayan T.; Kumar, Vinay V.; Brieger, Jürgen; Frerich, Bernhard; Kämmerer, Peer W.
• Is Part Of: Journal of oral pathology & medicine. Volume 46:Number 9(2017)
• Page Start: 710
• Page End: 716
• Publication Date: 2017-02-07
• Subjects: mean microvessel density -- oral cancer -- precancerous lesions -- tumour progression -- vascular endothelial growth factor; Dentistry -- Periodicals; Teeth -- Diseases -- Periodicals; 617
• DOI: 10.1111/jop.12544
• Languages: English
• ISSNs: 0904-2512

Abstract

Abstract : Background: Aim of the study was to assess the role of angiogenesis in the process of malignant transformation of clinical diagnosed oral leucoplakia (OL). Materials and methods: A total of 131 histological preparations [oral leukoplakia/hyperkeratosis without dysplasia (OL; n = 49), oral leukoplakia/hyperkeratosis with mild dysplasia (OL‐SIN1; n = 33), with moderate dysplasia (OL‐SIN2; n = 13) and leukoplakia‐derived oral squamous cell carcinoma (OL‐OSCC; n = 36)] were evaluated for microvessel density (MVD), vessel diameter as well as for vascular endothelial growth factor (VEGF‐A) expression. Data were compared within the groups. Results: For MVD, there were significant differences between OL and OL‐SIN 2/OL‐OSCC ( P < 0.05) and between OL‐SIN 1 and OL‐OSCC ( P < 0.05). For OL‐OSCC, vessel diameters were significantly increased compared with OL ( P < 0.05). Expression of VEGF‐A increased significantly gradually from OL‐SIN 1 to OSCC (each P < 0.05). This was especially evident for lesions of the tongue when compared to the others. Conclusion: Angiogenesis increases during the transition from OL through dysplasia to OL‐OSCC. In particular, OL‐OSCCs of the tongue, VEGF‐A expression may be used for estimation of malignant progression of OL.