[LB.01.17] SEASONAL ARTERIAL STIFFNESS CHANGES IN TREATED HYPERTENSIVE PATIENTS WITH DIFFERENT BLOOD PRESSURE PHENOTYPES. (September 2017)

• Record Type: Journal Article
• Authors: Koshelyaevskaya, Y.; Smirnova, M.; Gorbunov, V.; Volkov, D.; Deev, A.; Boytsov, S.; Furman, N.; Dolotovskaia, P.; Shamiunov, M.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523451.13686.3e
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: It is known that blood pressure (BP) is generally higher in winter (W) than in summer (S). But the studying of seasonal BP changes mechanisms is incomplete. Some scientists supposed that one of the mechanisms is seasonal dynamics of arterial stiffness (AS). The seasonal BP and AS changes are probably interrelated with seasonal dynamics of cardiovascular morbidity and mortality. We supposed, the relation between ambulatory BP (ABP) and clinical BP (CBP) [BP phenotypes; BPPh] might also depend on the season and AS. The aim of our study was to estimate the seasonal differences in AS parameters in treated hypertensive patients (THP) with different BPPh. Design and method: The ambulatory patients from the ABP monitoring database were selected according with criteria: antihypertensive treatment (>2 weeks; AHT), CBP and ABPM records in W and S. ABPM was performed by the device with algorithm for AS calculation. BPPh definitions: normotension (NT), masked uncontrolled hypertension (MUH), uncontrolled hypertension (UH). AS parameters (mean for 24 h): pulse wave velocity (PWV), maximum rate of BP increase (Dp(dt)), central augmentation index (AIxao) and peripheral (AIx). Results: 469 patients were selected. The main characteristics of BPPh are presented in the Table1. The antihypertensive therapy did not differ significantly in 3 groups. The seasonal dynamics of mean AS parameters with sex and age adjustment in BPPh differed slightly. We compared AS parameters (in quintiles from min to max) between BPPh. Figure. No caption available. The upper (3–5th) quintiles of the most AS indices (Dp(dt), AIx, AIxao) in MUH and UH were significantly higher than in NT(p < 0.05). But this pattern was found for the S only. The 4th quintiles of PWV was higher in UH vs. NT in W and S (p < 0.005). We found no substantial differences in AS parameters in UH vs. MUH Conclusions: Our study confirms seasonal changes in some of AS parameters in THP with different BPPh. The significant differences of AS parameters in NT vs. MUH and the absence of these AS differences in most of the parameters in MUH vs. UH may be one of the confirmations of the high cardiovascular risk in MH.