[PP.09.29] DISTRIBUTION OF CENTRAL AORTIC PRESSURE VALUES AND HIDDEN CENTRAL HYPERTENSION IN A LARGE COHORT OF ARGENTINA. (September 2017) - Obregon, S.
Abstract : Objective: The objetive is to determine the distribution of central aortic pressure values in a large cohort of Argentina, and the distribution of elevated central aortic pressure values in normotensives and controlled hypertensives. Design and method: From a large prospective cohort of 10300 subjects in a cardiovascular prevention programme (2013–2015), 8249 individuals were evaluated with central aortic pressure measurements (median arterial pressure calibration / Mobil-O-Graph, IEM, Germany). Associations with cardiovascular risk factors and other hemodynamic variables were performed in a group of 1473 normotensive people with complete clinical data, and also a group of 945 controlled hypertensives (bSBP/bDBP <140/90 mm Hg). Elevated aSBP was considered as 130 mm Hg or higher. Analysis of variables was performed with Excel 2016 and SPSS 22. Results: More than a half (53.3%) of the total population (54.5 ± 13.4 years; 61.2% male; bSBP/bDBP 128.8 ± 15.9/83.4 ± 11.4 mm Hg; cSBP/cDBP 132.8 ± 18.7/85 ± 11.8 mm Hg) were observed with an elevated aSBP (56.3 ± 13.8 years; 67.8% male; bSBP/bDBP 137.9 ± 14.5/87.9 ± 11.4 mm Hg; cSBP/cDBP 146.2 ± 14.5/90.1 ± 11.6 mm Hg). In normotensives (52.5 ± 11.7 years; 58.1% male; bSBP/bDBP 123 ± 9.8/81.2 ± 9.1 mm Hg; cSBP/cDBP 126.4 ± 14/82.6 ± 9.4 mm Hg), elevated aSBP was found in a proportion of 33.9% (53.6 ± 12.2 years; 69.8% male; bSBP/bDBP 129.3 ± 7/84.4 ± 8.6 mm Hg; cSBP/cDBP 139.5 ± 8.5/86.5 ± 8.9 mm Hg). In controlled hypertensives (52.5 ± 11.7 years; 67.7% male; bSBP/bDBP 123 ± 9.8/81.2 ± 9, 1 mm Hg; cSBP/cDBP 126.4 ± 14/82.6 ± 9.4 mm Hg), 50% were observed with elevated aSBP (59.6 ± 10 years; 71.9% male; bSBP/bDBP 126.8 ± 9.1/83.6 ± 9 mm Hg; cSBP/cDBP 133.3 ± 13/85.5 ± 9.5 mm Hg). Conclusions: A large proportion of patients with elevated aSBP was observed in this population of Argentina, both in one third of normotensive patients and half of controlled hypertensives. This data contributes to considering the so called hidden central hypertension as a frequent clinical situation for future hypertension research and management.