[PP.10.02] METABOLIC SYNDROME PRECIPITATES DETERIORATION OF ENDOTHELIAL FUNCTION IN YOUNG ADULTS. (September 2017)

• Record Type: Journal Article
• Authors: Terentes-Printzios, D.; Vlachopoulos, C.; Xaplanteris, P.; Ioakeimidis, N.; Angeis, A.; Georgakopoulos, C.; Pietri, P.; Skliros, N.P.; Tousoulis, D.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523429.28040.e7
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Vascular senescence, as assessed by structural and functional properties of the arteries, and metabolic syndrome (MS) are independent prognostic factors of cardiovascular risk. We examined whether MS precipitates the progression of vascular senescence. Design and method: One hundred and forty-two subjects (mean age 52 years, 94 men) with no established cardiovascular disease were investigated in two examinations over a 2-year period (mean follow-up visit 1.84 years). Metabolic syndrome was defined by the ATP III criteria. Subjects had at the beginning and end of the study determinations of carotid-femoral pulse wave velocity (PWV), aortic augmentation index corrected for heart rate (AIx75), brachial flow-mediated dilatation (FMD), nitroglycerin-mediated dilatation (NMD) and carotid intima-media thickness (cIMT). Based on these measurements the annual absolute changes were calculated. Results: At baseline patients with MS compared with patients without MS had lower values of FMD (6.0% vs. 7.0%, P = 0.025), but there were no statistically significant differences for PWV (7.04m/s vs. 7.26m/s, P = 0.242), AIx@75 (19.9% vs. 20.3%, P = 0.846) and cIMT (0.68 mm vs. 0.68 mm, P = 0.957). For the overall population, there were no statistically significant differences in the annual absolute changes of PWV, NMD, FMD, AIx75 and cIMT (p > 0.05). However, when a subgroup of patients <60 years with more rapid progression of endothelial aging was investigated, MS was associated with almost 7 times higher annual change of FMD [−0.89% (95% CI: −1.50 to −0.28) in patients with MS vs. −0.13% (95% CI: −0.36 to 0.10) in patients without MS, P = 0.032]. This difference was not evident in the other vascular biomarkers. Conclusions: Presence of MS is associated with deteriorated endothelial function as well as accelerated progression of endothelial dysfunction, especially in young adults. Figure. No caption available.